Introduction to zebrafish: current discoveries and emerging technologies for neurobehavioral toxicology and teratology.

摘要

This special issue of Neumtoxicology and Teratology "Zebrafish: Current Discoveries and Emerging Technologies" brings together the latest research concerning the use of zebrafish models for screening and mechanistic studies in neurobehavioral toxicology. The goal is not only to collect, in one place, the cutting-edge research findings in neurotoxicology obtained with the zebrafish model, but also to provide reviews of the key methods needed to the use of zebrafish for future neurotoxicological research.The zebrafish (Danio rerio) model is rapidly maturing into a major platform for investigating the molecular and cellular mechanisms of developmental neurobehavioral toxicology, and for increasing the throughput for screening large numbers of chemicals for developmental neurotoxicity. In 2004, Neurotoxicology and Teratology published a special issue, recognizing the promise of the zebrafish model for neurotoxicology research. In the ensuing seven years, zebrafish have proven useful in the study of the developmental aspects of neurotoxicology. Important recent advances in this field have been achieved in making another special zebrafish issue timely.