Recent discoveries on the functions of astrocytes in the copper homeostasis of the brain: A brief update

摘要

In the last two decades, there has been widespread acknowledgment of the pivotal role played by astrocytes in diverse aspects of central nervous system functioning. Astrocytes are crucial for the homeostasis of the copper in the central nervous system as evident by its proficiency in acquisition, trafficking, and export of copper. Moreover, the imbalance in copper homeostasis and impairment in astrocyte functioning are increasingly being recognized as an important contributing factor in the development of neurodegeneration and cognitive waning. In this review, we discuss the most recent advances in the field of copper homeostasis in astrocytes along with briefly outlining the copper dyshomeostasis associated hepatocerebral and neurodegenerative diseases.