Freeze dried ondansetron: first observations with the fast dissolving oral antiemetic Zofran Zydis for the prophylaxis of the cisplatin-induced emesis in gynecological cancer patients.

摘要

Oral antiemetics are seldom taken by patients (women, children or those having tumors of the buccal area, mouth or esophagus), who find it difficult to swallow. In addition to anatomical reasons, the side effects of cytostatics require medication. Fast dissolving ondansetron is a new preparation, which instantaneously disintegrates and disperses in the saliva. The purpose of this paper was to evaluate the antiemetic effectivity of the product Zofran Zydis. Thirty six patients treated with cisplatin (50 mg/m2) in 55 chemotherapy courses were given 2x8 mg fast dissolving ondansetron in a prospective non randomised study. 75% complete response and 11% major response rates were found. Authors conclude that fast dissolving ondansetron is a new and effective preparation that enriches the panel of available supporting drugs.