Irreversible electroporation is a safe and feasible option for focal therapy

摘要

A small clinical study from groups in London and Sydney has shown that irreversible electroporation (IRE) is an effective treatment for prostate tumours, with an excellent safety and adverse-effect profile. The concept of focal therapy to minimize the negative effects of prostate cancer treatment is well established. However, the therapeutic outcomes of focal therapies are variable and are often associated with adverse effects, including rectourethral fistulae. IRE uses nonthermal energy to create nanopores within the-cell membrane of tumour cells, which results in cell death, and can be targeted specifically to cancerous cells without affecting surrounding tissue.