Officinalioside, a new lignan glucoside from Borago officinalis L.

摘要

A new lignan glucoside, officinalioside (1), was isolated from n-BuOH fraction of the aerial parts of Borago officinalis L., together with four known compounds: actinidioionoside (2), roseoside (3), crotalionoside C (4) and kaempferol 3-O--D-galactopyranoside (5). The structure of the new compound was established by means of spectroscopic and chemical analyses. Compounds 1 and 2 showed a moderate DPPH radical scavenging activity (IC50: 52.6 +/- 1.70 and 41.3 +/- 0.25M, respectively) comparable with that of the standard trolox (16.6 +/- 2.2M) without any significant cytotoxicity towards human cell line A549 (IC50>100 mu M).