Gut microbiota: Post-transplant complications associated with gut flora

摘要

The researchers performed orthotopic transplantation of kidneys to immunodeficient mice, to enable transplantation in the absence of an immune response. "After the surgical inflammation had subsided, we administered monoclonal antibodies that recognized the donor major histocompatibility complex antigens," explains Baldwin. "This approach eliminated all other causes of inflammation and rejection. It also enabled us to control the time at which AMR was initiated and to carefully follow the consequences."