A new report provides further evidence for a link between severe hyposmia and neuropsychiatric manifestations of Parkinson disease (PD). "The possibility that olfactory impairment might be used to predict features such as dementia and psychosis, that are often the most troublesome symptoms later in the disease course, is the impetus for this area of research," states John Duda, the study's corresponding author. Several previous studies described correlations between this very early nonmotor manifestation of PD and disease severity or progression, but nonlinear relationships between olfactory dysfunction and clinical measures of disease severity limited its utility as abiomarker.
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