A population-based cohort study suggests that fibrate use is associated with increases in serum creatinine level among elderly patients. The investigators suggest that caution should therefore be exercised when prescribing fibrates to these patients, by starting the prescription at a low dosage and closely monitoring renal function.Fibrates are commonly used to treat dyslipidemia and can reduce the risk of major cardiovascular events. However, case reports, small clinical studies and randomized, controlled trials indicate that fibrate use is associated with an increase in serum creatinine level. "Elderly patients have a high prevalence of dyslipidemia and chronic kidney disease (CKD) and are frequently excluded from randomized trials", write the authors of this study. The investigators therefore carried out this study, published in Annals of Internal Medicine, to characterize acute renal outcomes associated with fibrate use in elderly patients and the effect of these outcomes on health-care use."Our primary objective was to examine the association between a new prescription for fibrate and renal outcomes within 90 days."
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