RAS BLOCKADE Nephroprotection by dual RAS blockade-a welcome back

Ruggenenti Piero; Remuzzi Giuseppe

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RAS BLOCKADE Nephroprotection by dual RAS blockade-a welcome back

机译：RAS封锁通过双重RAS封锁进行肾脏保护-欢迎回来

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A new meta-analysis shows that dual blockade of the renin-angiotensin system is the most effective approach to prevent end-stage renal disease in patients with diabetes and kidney disease. Combination therapy should therefore be reconsidered as the most powerful tool for nephroprotection, provided that treatment is individually tailored by careful dose-titration.

机译：一项新的荟萃分析表明，双重阻断肾素-血管紧张素系统是预防糖尿病和肾脏疾病患者终末期肾脏疾病的最有效方法。因此，联合治疗应重新考虑为保护肾功能最有效的工具，前提是应通过谨慎的剂量滴定来个性化治疗。

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《Nature reviews. Nephrology》 |2015年第9期|共2页
作者
Ruggenenti Piero; Remuzzi Giuseppe;
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正文语种 eng
中图分类泌尿科学（泌尿生殖系疾病）;
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1. RAS BLOCKADE Nephroprotection by dual RAS blockade-a welcome back [J] . Ruggenenti Piero, Remuzzi Giuseppe Nature reviews. Nephrology . 2015,第9期

机译：RAS封锁通过双重RAS封锁进行肾脏保护-欢迎回来
2. RANKL blockade improves efficacy of PD1-PD-L1 blockade or dual PD1-PD-L1 and CTLA4 blockade in mouse models of cancer [J] . Elizabeth Ahem, Heidi Harjunpaa, Jake S. ODonnell, Oncoimmunology. . 2018,第6期

机译：Rankl阻断改善了PD1-PD-L1阻断或双PD1-PD-L1和CTLA4阻断在癌症模型中的疗效
3. Usefulness of intra-operative neuromuscular blockade monitoring and reversal agents for postoperative residual neuromuscular blockade: a retrospective observational study [J] . Gonzalo Domenech, Matías A. Kampel, María E. García Guzzo, BMC Anesthesiology . 2019,第1期

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4. A theoretical model for the dependency of heart rate on gradual vagal blockade by atropine [C] . Pyetan, E., Zoran, . 2001

机译：心律对阿托品逐步迷走神经阻滞的依赖性的理论模型
5. Overcoming Melanoma Immune Tolerance: Non-specific CTLA-4 Blockade/Interferon-alpha and Antigen Specific Immunization with TLR-9 Stimulation/Local GM-CSF as Components of a Melanoma Immunotherapeutic Strategy and Associated Biomarkers of Therapeutic Benefit. [D] . Tarhini, Ahmad A. 2011

机译：克服黑色素瘤的免疫耐受性：非特异性CTLA-4阻断/干扰素-α和抗原特异性免疫，TLR-9刺激/局部GM-CSF作为黑色素瘤免疫治疗策略的组成部分和相关的治疗有益生物标志物。
6. RANKL blockade improves efficacy of PD1-PD-L1 blockade or dual PD1-PD-L1 and CTLA4 blockade in mouse models of cancer [O] . Elizabeth Ahern, Heidi Harjunpää, Jake S. ODonnell, 2018

机译：RANKL阻断剂可提高PD1-PD-L1阻断剂或双重PD1-PD-L1和CTLA4阻断剂在癌症小鼠模型中的功效
7. RANKL blockade improves efficacy of PD1-PD-L1 blockade or dual PD1-PD-L1 and CTLA4 blockade in mouse models of cancer [O] . Elizabeth Ahern, Heidi Harjunpää, Jake S. ODonnell, 2018

机译：Rankl阻断提高了PD1-PD-L1阻断或双PD1-PD-L1和CTLA4阻断在癌症模型中的疗效

RAS BLOCKADE Nephroprotection by dual RAS blockade-a welcome back

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