Deficiency of antiproliferative family protein Ana correlates with development of lung adenocarcinoma

摘要

Lung cancer is a conglomeration of diseases of diverse etiology, divided into non-small-cell lung cancer (NSCLC) accounting for 80% of lung cancers, and small-cell lung cancer (SCLC) accounting for 20% of lung cancers. NSCLC comprises diverse histological subtypes including adenocarcinomas, squamous-cell carcinomas, large-cell carcinomas, and adenos-quamous carcinomas. Accumulating evidence shows that the most frequent alterations detected in lung cancers are p53 mutations, being detected in -90% of SCLC and in -50% of NSCLC.~(1)The Rb gene is also inactivated in -90% of SCLC, but in only 15% of NSCLC.~(1) In contrast, the pl6 gene, whose product inhibits Rb phosphorylation, is inactivated in -70% of NSCLC, but rarely in SCLC.~(1) Importantly, neither p53 nor Rb/ p16 is inactivated in certain numbers of lung cancer patients. Therefore, other genes whose inactivation is responsible for lung carcinogenesis remain to be clarified#