Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array

摘要

Epidemiological studies provide strong evidence for genetic predisposition to prostate cancer. Most susceptibility loci identified thus far are common, low-penetrance variants found through genome-wide association studies (GWAS; reviewed in ref. 1). Fifty-four loci have been identified so far1-6.Because the risks associated with common susceptibility alleles are modest (per-allele odds ratios, ORs, ranging from 1.10-1.25), it is likely that other predisposition loci for prostate cancer have been missed by previous studies and that such loci should be detectable by studies with larger sample sizes7. Here, we report the findings from an extensive follow-up of GWAS conducted as part of a collaborative study with the Breast Cancer Association Consortium (BCAC), Ovarian Cancer Association Consortium (OCAC) and The Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) as part of the COGS initiative.