In brief.

摘要

Sensory-evoked calcium signalling has been detected in dendrites in mouse visual cortex through conventional two-photon imaging. The precise localization of such signalling has, however, remained unclear. Using a new variant of two-photon imaging, Chen et al. show that sound-evoked dendritic calcium signalling in auditory cortical neurons from mice primarily occurs in spines. Moreover, they show that this signalling requires NMDA receptor activation, and that individual dendrites contain spines that respond to different frequencies.