PRAME in the frame

摘要

Ninety-five percent of melanomas, as well as many breast tumours and neuroblastomas, overexpress a tumour antigen called preferentially expressed antigen in melanoma (PRAME), but little is known about its potential oncogenic function. In their Cell paper, Rene Bernards and colleagues show that PRAME is an important modulator of retinoic acid signalling that promotes cell proliferation and survival.