IDENTIFICATION OF HLA-RESTRICTED PRAME PEPTIDE EPITOPES, PRAME-SPECIFIC T CELLS SUITABLE FOR 'OFF-THE-SHELF' TREATMENT OF CANCER EXPRESSING PRAME

摘要

The invention pertains to a method for treating a cancer which expresses PRAME using T cells which recognize specific peptide epitopes of PRAME, to a method for producing T cells that target cancer cells expressing PRAME, the peptide epitopes of PRAME themselves and to compositions and methods of treatment using these peptides.