Dib-Hajj, S.D.a b , Yang, Y.a b , Black, J.A.a b , Waxman, S.G.a b The Na v 1.7 sodium channel: From molecule to man

摘要

The voltage-gated sodium channel NaV 1.7 is preferentially expressed in peripheral somatic and visceral sensory neurons, olfactory sensory neurons and sympathetic ganglion neurons. NaV 1.7 accumulates at nerve fibre endings and amplifies small subthreshold depolarizations, poising it to act as a threshold channel that regulates excitability. Genetic and functional studies have added to the evidence that NaV 1.7 is a major contributor to pain signalling in humans, and homology modelling based on crystal structures of ion channels suggests an atomic-level structural basis for the altered gating of mutant NaV 1.7 that causes pain.