Model Drug Delivery System Based on Nanodiamonds

摘要

This study investigates the possibility of using a detonation nanodiamond as a targeted drug-deliv-ery vehicle. Supramolecular complexes composed of nanodiamond particles and address protein molecules (nanodiamond–IgG~(I125) and RAM–nanodiamond–BSA~(I125)) have been obtained. In vitro experiments have revealed that these complexes are stable and exhibit high colloidal stability in blood serum, as well as passivity to the cellular components of blood. It has been shown that, after the simultaneous covalent immobilization of two proteins (rabbit anti-mouse antibody (RAM) and bovine serum albumin (BSA~(I125))) on the nanoparti-cles, the resulting complex is able to specifically bind to the target antigen (mouse IgG).