Radio fluorination and positron emission tomography (PET) as a newapproach to study the in vivo distribution and elimination of the advancedglycation endproducts N-epsilon-carboxymethyllysine (CML) andN-epsilon-carboxyethyllysine (CEL)

Bergmann R; Helling R; Heichert C; Scheunemann W; Mading P; Wittrisch

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Radio fluorination and positron emission tomography (PET) as a newapproach to study the in vivo distribution and elimination of the advancedglycation endproducts N-epsilon-carboxymethyllysine (CML) andN-epsilon-carboxyethyllysine (CEL)

机译：无线电氟化和正电子发射断层扫描（PET）作为研究晚期糖化终产物N-ε-羧甲基赖氨酸（CML）和N-ε-羧乙基赖氨酸（CEL）的体内分布和消除的新方法

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After synthesis of fluorine-18 labelled analogues by [18F]fluorobenzoylation at the alpha -amino group, biodistribution and elimination of individual advanced glycation endproducts, namely N-epsilon-carboxymethyllysine and N-epsilon-carboxyethyllysine, were studied in comparison to lysine in rats after intravenous injection using positron emission tomography (PET).

机译：在α-氨基上通过[18F]氟苯甲酰化合成氟-18标记的类似物后，与赖氨酸相比，在大鼠中研究了N-ε-羧甲基赖氨酸和N-ε-羧乙基赖氨酸的各个高级糖基化终产物的生物分布和消除使用正电子发射断层扫描（PET）静脉注射后。

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《Nahrung》 |2001年第3期|共7页
作者
Bergmann R; Helling R; Heichert C; Scheunemann W; Mading P; Wittrisch;
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正文语种 eng
中图分类食品工业;
关键词
Age-dependent accumulation; Maillard reaction; End-product; Diabetes-mellitus; Lens proteins; N-epsilon-(carboxymethyl)lysine; Receptor; Biodistribution; Uremia; Mice;

机译：年龄依赖性积累;美拉德反应;终产物;糖尿病;透镜蛋白;N-ε-（羧甲基）赖氨酸;受体;生物分布;尿毒症;小鼠;

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机译：无线电氟化和正电子发射断层扫描（PET）作为研究晚期糖化终产物N-ε-羧甲基赖氨酸（CML）和N-ε-羧乙基赖氨酸（CEL）的体内分布和消除的新方法
2. Feasibility of optimizing the dose distribution in lung tumors using fluorine-18-fluorodeoxyglucose positron emission tomography and single photon emission computed tomography guided dose prescriptions. [J] . Das SK, Miften MM, Zhou S, Medical Physics . 2004,第6期

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Radio fluorination and positron emission tomography (PET) as a newapproach to study the in vivo distribution and elimination of the advancedglycation endproducts N-epsilon-carboxymethyllysine (CML) andN-epsilon-carboxyethyllysine (CEL)

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