Protective effects of water/methanol extracts of cricket on the acute hepatic damages in the ICR-mice induced by administration of CCl_4

摘要

Water and methanol extracts of cricket were examined for their liver protective effects against CCl_4-intoxication in ICR-mice. Serum transaminases (S-GOT and S-GPT), lactate dehydrogense (LDH) and glutathione-S-transferase (GST) activities and TBARS(Thiobarbiturate-reactive substances) content were measured for evaluation of liver protective effects. The activities of GOT, GPT, LDH and hepatic content of lipid peroxide after CCl_4-treatment were higher than normal control but those levels decreased to 74, 50, 101 and 40 percent, respectively, by the treatment of cricket methanol extract. The anti-fatigue effects of water and methanol extracts investigated by an acute weight-loaded forced swimming test showed significantly prolonged swimming timein the mice administered cricket extracts. These results suggest us that water/alcohol extract of G. bimaculatus may be used as a liver protective food.