Letter Vitamin K cream reduces reactions at the injection site in patients with relapsing- remitting multiple sclerosis treated with subcutaneous interferon beta - VIKING study

摘要

Dear Editor, Multiple sclerosis therapy with injectable drugs is still dogged by possible local side effects (injection site pain, burning, erythema and necrosis), with the danger of poor adherence and consequently low efficacy. Any approach that reduces local reactions serves to increase patient compliance to treatments.1'2 Topical vitamin K seems to be useful to prevent, or at least to reduce, the development of burning sensations. It is thought to act on the production of coagulation factors taking part in a reaction involved in calcium binding and in the interaction between coagulation factors and phospholipid layers.