N-Polybenzylated alicyclic 1,2-diamines:cytotoxicity and G1 phase arrest in cancer cell line

Antonio Caldarelli; Valeria De Biasio; Giovanni B. Giovenzana; Gianpiero Mastronardo; Roberto Negri

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N-Polybenzylated alicyclic 1,2-diamines:cytotoxicity and G1 phase arrest in cancer cell line

机译：N-聚苄基脂环族1,2-二胺：癌细胞系的细胞毒性和G1期阻滞

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Cytotoxicity in the μM range was observed in cancer cell lines treated with N,N,N',N'-tetrabenzyl-4,5-diamino-2-cyclopentenone. Cell cycle analysis on HeLa cells showed a clear G1 phase arrest. A preliminary SAR on structural analogs was performed in order to identify the pharmacophores.

机译：在用N，N，N'，N'-四苄基-4,5-二氨基-2-环戊烯酮处理的癌细胞系中观察到μM范围的细胞毒性。 HeLa细胞的细胞周期分析显示出清晰的G1期停滞。对结构类似物进行了初步SAR，以鉴定药效团。

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《Molecular diversity 》 |2014年第4期| 共8页
作者
Antonio Caldarelli; Valeria De Biasio; Giovanni B. Giovenzana; Gianpiero Mastronardo; Roberto Negri;
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正文语种 eng
中图分类分子物理学、原子物理学 ;
关键词
Cytotoxicity; Tetrabenzyldiaminocyclopentenone; G1 phase arrest; SAR;

机译：细胞毒性;四苄基二氨基环戊烯酮;G1期阻滞;SAR;

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1. N-Polybenzylated alicyclic 1,2-diamines:cytotoxicity and G1 phase arrest in cancer cell line [J] . Antonio Caldarelli, Valeria De Biasio, Giovanni B. Giovenzana, Molecular diversity . 2014 ,第4期

机译：N-聚苄基脂环族1,2-二胺：癌细胞系的细胞毒性和G1期阻滞
2. Chalcone HTMC causes in vitro selective cytotoxicity, cell-cycle G1 phase arrest through p53-dependent pathway in human lung adenocarcinoma A549 cells, and in vivo tumor growth suppression. [J] . Rao YK, Kao TY, Ko JL, Bioorganic and Medicinal Chemistry Letters . 2010 ,第22期

机译：查耳酮HTMC引起体外选择性细胞毒性，人肺腺癌A549细胞中通过p53依赖性途径引起的细胞周期G1期阻滞和体内肿瘤生长抑制。
3. Chalcone HTMC causes in vitro selective cytotoxicity, cell-cycle G1 phase arrest through p53-dependent pathway in human lung adenocarcinoma A549 cells, and in vivo tumor growth suppression. [J] . Rao YK, Kao TY, Ko JL, Bioorganic and Medicinal Chemistry Letters . 2010 ,第22期

机译：查耳酮HTMC引起体外选择性细胞毒性，人肺腺癌A549细胞中通过p53依赖性途径引起的细胞周期G1期阻滞和体内肿瘤生长抑制。
4. Induction of G2/M phase arrest and apoptosis by potent antitumor thirty-two-8-oxo-8H-acenaphtho1,2-bpyrrole-9-carbonitrile derivative in human cervix carcinoma cells [C] . rn, rn, rn Asian Pacific Confederation of Chemical Engineering congress . 2008

机译：强效抗肿瘤三十二-8-氧-8H-ac 1,2-b吡咯-9-腈衍生物在人宫颈癌细胞中诱导G2 / M期阻滞和凋亡
5. Small molecule modulation of the cell cycle: Discovery of anticancer compounds that induce G1- and M-phase cell cycle arrest and characterization of their modes of action. [D] . Leslie, Benjamin. 2009

机译：细胞周期的小分子调节：诱导G1期和M期细胞周期停滞及其作用方式表征的抗癌化合物的发现。
6. Polyphenol-rich extract of Salvia chinensis exhibits anticancer activity in different cancer cell lines and induces cell cycle arrest at the G0/G1-phase apoptosis and loss of mitochondrial membrane potential in pancreatic cancer cells [O] . QUAN ZHAO, XUE-CHEN HUO, FU-DONG SUN, -1

机译：丹参中富含多酚的提取物在不同的癌细胞系中均表现出抗癌活性并诱导胰腺癌细胞的G0 / G1期细胞周期停滞凋亡和线粒体膜电位的丧失。
7. Penta-O-galloyl-β-D-glucose induces G1arrest and DNA replicative S-phase arrest independently of P21 cyclin-dependent kinase inhibitor 1A, P27 cyclin-dependent kinase inhibitor 1B and P53 in human breast cancer cells and is orally active against triple-negative xenograft growth [O] . Yubo Chai, Hyo-Jeong Lee, Ahmad Ali Shaik, 2010

机译：Penta-O-galloyl-β-D-葡萄糖在人乳腺癌细胞中独立于P21细胞周期蛋白依赖性激酶抑制剂1A，P27细胞周期蛋白依赖性激酶抑制剂1B和P53诱导G1阻滞和DNA复制性S期阻滞，并且对三联体具有口服活性负异种移植生长

N-Polybenzylated alicyclic 1,2-diamines:cytotoxicity and G1 phase arrest in cancer cell line

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