A gene-centric human proteome project: HUPO--the Human Proteome organization.

摘要

The success of the Human Genome Project (1, 2) has provided a blueprint for the gene-encoded proteins potentially active in all of the hundreds of cell types that make up the human body. Yet we still have limited knowledge regarding a majority of the approximately 20,000 protein-coding human genes discovered through the genome project (3, 4). At present,about 8,000 (38%) of these genes lack experimental evidence at the protein level (UniProt), and for many others there is very little information related to protein abundance, distribution, subcellular localization, and function.