Deep proteome markers of human biological aging and methods of determining a biological aging clock

摘要

A method of creating a biological aging clock for a subject can include: (a) receiving a proteome signature derived from a tissue or organ of the subject; (b) creating input vectors based on the proteome signature; (c) inputting the input vectors into a machine learning platform; (d) generating a predicted biological aging clock of the tissue or organ based on the input vectors by the machine learning platform, wherein the biological aging clock is specific to the tissue or organ; and (e) preparing a report that includes the biological aging clock that identifies a predicted biological age of the tissue or organ.