Safety Evaluation of the Overintake of Sodium Hyaluronate

摘要

Sodium hyaluronate is a functional food material that helps improve dry skin conditions. In this study, we evaluated the safety of sodium hyaluronate overintake in Japanese individuals. The study included 11 healthy individuals (males = 3, females = 8) who consumed sodium hyaluronate (1,290 mg/day) for 4 weeks. The participants underwent blood and urine tests before and 2 and 4 weeks after the intake of sodium hyaluronate. Notably, sodium hyaluronate intake did not lead to any abnormal findings or adverse events. This study suggests that sodium hyaluronate intake is safe for healthy adults (UMIN000050106). Sodium hyaluronate (SH) is a high-molecular-weight mucopolysaccharide that comprises repeating structures of disaccharide units containing N-acetylglucosamine and glucuronic acid (Laurent, 1987). This mucopolysaccharide is synthesized in all animals and some microorganisms, and it is found in vivo in various connective tissues and organs, including skin, synovial fluid, blood vessels, serum, brain, cartilage, heart valves, and umbilical cord (Laurent and Fraser, 1992). SH is widely used in Pharmaceuticals, cosmetics, and food ingredients. Moreover, it is a healthy functional food with skin moisturizing and knee discomfort relief functions (Oe et al., 2016; Kawada et al, 2014).^g>hyaluronic acid , hyaluronan ,hyaluronate , overdose , blood test