Acetylcholinesterase Inhibitor Activity of Some 5-Nitrothiophene-Thiazole Derivatives

摘要

The potential anticholinesterase characteristics of some thiazole derivatives (2a–2j), including the 5-nitrothiophene moiety, were examined in this work. 1H-NMR, 13C-NMR, and HRMS spectral data were used to determine the structure of the compounds. Using a modified Ellman's spectrophotometric approach, each compound was tested for its ability to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) enzymes. It was determined that the compounds exhibited inhibition of between 33.66–47.96 against AChE and 13.03–63.29 against BuChE at 80 µg/mL concentration.