Treatment-related acute myeloid leukemia characterized by t(11;20)(p15;q11) and del(9)(q22). Haimi, Motti); Irit, Avivi (corrected to Avivi, Irit); Nivin, Moustafa (corrected to Moustafa, Nivin); Olfat, Aboleil (corrected to Aboleil, Olfat); Ruth, Ge

摘要

Chromosomal aberrations are considered causal events in the process of leukemic transformation. They are frequently associated with therapy-related myelodysplastic syndromes and acute myelogenous leukemia, and are thought to result from exposure to cytotoxic drugs and/or from radiation therapy . Here, we describe for the first time an acute myeloid leukemia (AML) case with two distinct cytogenetic abnormalities, namely t(ll;20)(pl5;qll.2) and del(9q), combined together and conferring a poor prognosis.