Oral delivery of drugs by means of solid lipid nanoparticles

摘要

Aim. Oral drug delivery can be improved through nanoencapsulation of drugs into lipid carriers. This approach takes advantages of the fact that lipids have absorption promoting properties both for Mpophilic and hydrophilic drugs. Thus, if problematic drugs, e.g. poorly soluble molecules such as ibuprofen, are incorporated into lipid carriers, bioavailability of such drug molecules might be improved. In the present paper lipid based carrier systems (i.e. solid lipid nanoparticles, SLN) composed of well tolerated lipids have been produced and physicochemically characterized.