N-Carboxymethyl Chitosan Coated Solid lipid Nanoparticles for oral delivery of Insulin

摘要

N-Carboxymethyl chitosan coated Insulin loaded Solid Lipid Nanoparticles (SLN) were prepared with a view to increase the encapsulation efficiency and protect insulin from gastric environment. Apart from protection, the polymer can also acts as permeation enhancer. Upon oral administration, polymer coated Insulin loaded SLN demonstrated about 33% reduction in the blood glucose levels.