Ion-Pair Formation in Pharmaceutical Analysis. Conductimetric Determination of Promazine, Chlorpromazine, Promethazine, Imipramine and Ciprofloxacin Hydrochlorides in Pure Form, Drug Formulations and Urine

摘要

Potassium ferricyanide and sodium tetraphenylborate were used as titrants for the conductimetric determination of promazine HCl, chlorpromazine HCl, promethazine HCl, imipramine HCl and ciprofloxacin HCl through ion-associate complex formation. THe molar combining ratio, effects of dilution of titrant, temperature and solvent were studied. The accuracy of the method is indicated by excellent recovery (99.50-99.96%). The sensitivity of the proposed method is discussed and the results are compared with the pharmacopoeial or the official methods. The suggested method has been applied for the analysis of the mentioned compounds in their pharmaceutical formulations and urine.