Molecular Imprinting-Chemiluminescence Determination of Norfloxacin Using a Norfloxacin-Imprinted Polymer as the Recognition Material

摘要

A selective molecular imprinting-chemilu-minescence method was developed for the determination of norfloxacin by using a norfloxacin-imprinted polymer as recognition material and the Ce(IV)-sodium sulfite-norfloxacin chemiluminescence reaction as the detection system.The chemiluminescence intensity responded linearly to the concentration of norfloxacin within l.0x 10~(-7) approx 1.0x l0~(-5) mol L~(-1) with a detection limit of 3 x 10~(-8) mol L~(-1).The relative standard deviation for 5.0x 10~(-7)mol L~(-1) norfloxacin solution was 2.4% (n = 7).This method was applied to the determination of norfloxacin in urine samples,and the results obtained were satisfactory.