Antibiotic resistance reversal (ARR) in Gram-negative and Gram-positive pathogens employing electric fields

摘要

Antibiotic resistance in clinical bacterial pathogens has now become a major global public health problem. In certain infections (e.g., chronic pulmonary infections in patients with cystic fibrosis), antibiotic resistance has become critical in the treatment of Pseudomonas aeruginosa, due to widespread resistance, which causes a major treatment dilemma. In addition, bacteria are developing resistance more quickly than new efficacious antibiotics are being produced, leading to an eventual drain on the effect of antibiotics. Therefore, several antibiotic stewardship policies have recently been introduced into hospitals in order to promote the judicious use of remaining antibiotics in an attempt to prolong the efficacy of antibiotics for treatment in human infections.