Susceptibility of Escherichia coli and Staphylococcus aureus isolates from a district general hospital in the U.K. to tigecycline and other antimicrobials.

摘要

The global prevalence of antimicrobial-resistant bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli, cannot be underestimated. These multidrug-resistant phenotypes severely limit available therapeutic options, leading to morbidity, increased costs and extended hospitalisation.This study reports on tigecycline activity, evaluated using Epsilometer test (Etest) strips, against contemporary ESBL-E. coli and MRSA isolates from a district general hospital in the UK. It also assesses susceptibilities of these isolates to a wide range of antibiotics, some of which are commonly used for the treatment of MRSA or ESBL-E. coli infections. These antimicrobial susceptibility patterns are compared to isolates of methidllin-sensitive S. aureus (MSSA) and isolates of non-ESBL E. coli.