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首页> 外文期刊>Metabolism: Clinical and Experimental >Effect of visceral fat accumulation on uric acid metabolism in male obese subjects: visceral fat obesity is linked more closely to overproduction of uric acid than subcutaneous fat obesity.
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Effect of visceral fat accumulation on uric acid metabolism in male obese subjects: visceral fat obesity is linked more closely to overproduction of uric acid than subcutaneous fat obesity.

机译：内脏脂肪积累对男性肥胖受试者尿酸代谢的影响：与皮下脂肪肥胖相比，内脏脂肪肥胖与尿酸过量产生的关系更为密切。

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We investigated the relationship between uric acid (UA) metabolism and fat distribution in 36 obese men with a mean +/- SD age of 38 +/- 16 years and mean body-mass index (BMI) of 34 +/- 4 kg/m2. Subjects were divided into two groups: subcutaneous fat obesity (SFO) and visceral fat obesity (VFO), according to their abdominal fat distribution based on the results of computed tomography (CT). SFO was defined as having a ratio of visceral fat area (VFA) to subcutaneous fat area (V/S) of less than 0.4, and VFO was defined as having a V/S ratio > or = 0.4. The levels of serum total cholesterol (T-Chol), triglyceride (TG), and fasting plasma glucose (FPG), and the diastolic blood pressure (dBP) were significantly higher in the VFO group than in the SFO group. Serum UA levels were much higher in both the SFO and VFO groups than in the non-obese control group (492 +/- 107 and 474 +/- 90 v 309 +/- 48 micromol/L, respectively). The 24-hour urinary urate excretion (u-UA24h) and the UA clearance (Cua) to creatinine clearance (Ccr) ratio were significantly higher in the VFO group than in the SFO group (3.75 +/- 1.43 v 2.69 +/- 1.12 mmol/d, P < .05; and 5.9% +/- 2.0% v 3.6% +/- 1.7%, P < .001, respectively). The frequency of hyperuricemia was markedly higher in both the SFO and VFO groups compared with the control group (71% and 73% v 0%, respectively). Although the high serum UA level seemed to be related to low u-UA24h in 80% of SFO subjects with hyperuricemia, this was the case in only 10% of VFO subjects. While 44% of VFO subjects with hyperuricemia were designated as an overproduction type. These results suggest that the mechanism of hyperuricemia in obesity may be affected by the difference in body fat distribution and that the assessment of body fat distribution and types of hyperuricemia is crucial for the treatment of obese patients with hyperuricemia.
机译：我们调查了36名平均+/- SD年龄为38 +/- 16岁，平均身体质量指数（BMI）为34 +/- 4 kg /的肥胖男性中尿酸（UA）代谢与脂肪分布之间的关系。平方米根据基于计算机断层扫描（CT）结果的腹部脂肪分布，将受试者分为两组：皮下脂肪肥胖症（SFO）和内脏脂肪肥胖症（VFO）。 SFO被定义为内脏脂肪面积（VFA）与皮下脂肪面积（V / S）之比小于0.4，并且VFO被定义为V / S之比≥0.4。 VFO组的血清总胆固醇（T-Chol），甘油三酸酯（TG）和空腹血糖（FPG）和舒张压（dBP）的水平明显高于SFO组。 SFO和VFO组的血清UA水平均比非肥胖对照组高（分别为492 +/- 107和474 +/- 90 v 309 +/- 48 micromol / L）。 VFO组的24小时尿尿排泄量（u-UA24h）和UA清除率（Cua）与肌酐清除率（Ccr）的比例明显高于SFO组（3.75 +/- 1.43 v 2.69 +/- 1.12 mmol / d，P <.05;和5.9％+/- 2.0％对3.6％+/- 1.7％，P <.001）。与对照组相比，SFO和VFO组的高尿酸血症发生率显着更高（分别为71％和73％vs 0％）。尽管在80％的高尿酸血症SFO受试者中，较高的血清UA水平似乎与低u-UA24h相关，但只有10％的VFO受试者就是这种情况。而高尿酸血症的VFO受试者中有44％被指定为生产过剩类型。这些结果表明，肥胖症中高尿酸血症的机制可能受到体内脂肪分布差异的影响，并且对体脂分布和高尿酸血症类型的评估对于肥胖高尿酸血症患者的治疗至关重要。

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