Influence of ubiquitln on fetal survival and full term rabbits derived from mothers with induced antiphospholipid syndrome

摘要

An assessment of the effect of bovine testis ubiquitin complex (TeUC) administered,to pregnant rabbits with experimentally induced antiphospholipid syndrome (APS) on the rabbit-fetuses intrauterine growth and survival rate was conducted. Group TeUC -44 offspring from mothers treated by an i.m. administration of TeUC on the 20th, 21st, 22nd and 26th days of pregnancy, 10 mg daily. Group IM - 62 offspring from mothers with experimentally induced antiphospholipid syndrome (APS) (immunized by cardiolipin administration). Group IM-TeUC - 48 offspring from rabbits with induced antiphospholipid syndrome (APS) and administered additionally TeUC in the same way as in the TeUC group. Control group consisted of 56 offspring, from rabbits treated by physiological saline. Conclusion: TeUC given during uncomplicated pregnancy has positive influence on neonatal rabbits' birth weight, survival and viability. TeUC given to pregnant rabbits with APS improves the rate of live born neonates as well as viability and postnatal survival in preterm born rabbits.