Toward Tract-Specific Fractional Anisotropy (TSFA) at Crossing-Fiber Regions with Clinical Diffusion MRI

摘要

Purpose: White matter fractional anisotropy (FA), a measure suggesting microstructure, is significantly underestimated with single diffusion tensor model at crossing-fiber regions (CFR). We propose a tract-specific FA (TSFA), corrected for the effects of crossing-fiber geometry and free water at CFR, and adapted for tract analysis with diffusion MRI (dMRI) in clinical research.