F-19, C-13 NMR analysis of an oxygen carrier, perfluorotributylamine, and perfluoropentanoic acid

摘要

NMR relaxation measurement of perfluorocarbons (PFCs), such as perfluorotributylamine (FTBA), is a convenient method for the determination of oxygen concentrations in tissues and tumors. Previous relaxation studies of FTBA used different F-19 NMR assignments causing some confusion. Fluorine-detected F-19, C-13 HMQC and HMBC and selectively F-19-decoupled C-13 NMR provided unequivocal F-19 and C-13 assignments for FTBA and perfluoropentanoic acid (FPA). Based on those assignments, C-13 spin-lattice relaxation time constants (T-1) and effective correlation times for FTBA and FPA are reported and discussed. Copyright (C) 2003 John Wiley Sons, Ltd. [References: 48]