Biospecific properties of random copolymers, 2 - Monte Carlo simulation of random methacrylate based terpolymers

摘要

Previous results obtained have shown that it was possible to create biospecific sites onto polymers through statistic modifications of polystyrene derivatives copolymer with given chemical groups or through synthesis of random methacrylate-based copolymers. Such polymers show biological activities (anticoagulant, cell proliferation modulation...) dependent of the global composition and thus of the statistical distribution of the functional groups, and the number of biospecific sites is simply correlated to the observed biological activity. The study of the radical terpolymerization allows us to use a Monte Carlo based synthesis simulation and to determine the occurrence frequency of three to twenty monomers sequences as a function of the conversion rate and the global composition. The comparison of the sequences occurrence curves as a function of the global composition of the polymers with the experimental cell proliferation inhibition curve led us to extract a series of eight monomers sequences with similar structure properties representing a group of biospecific sites responsible for the observed biological activity. [References: 9]