Preparation of Cationic Liposome Containing a Novel Water-Soluble Detergent and Its Application to Gene Delivery In Vitro

摘要

As gene delivery carrier vectors,various synthetic nonvi-ral vectors have been developed over the past decade.The synthetic vehicles for encapsulation and delivery of therapeutic genes are cationic liposomes and polymers,or the combination of both vectors.Some recent studies show that they express sufficient amounts of therapeutically active compounds in distal tumors,causing reduced tumor growth.For the synthetic carriers studied so far,liposome system is one of the most promising carriers for delivering therapeutic genes as well as biologically active molecules into mammalian cells.