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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Does supplementation with recombinant luteinizing hormone prevent ovarian hyperstimulation syndrome in down regulated patients undergoing recombinant follicle stimulating hormone multiple follicular stimulation for IVF/ET and reduces cancellation rate for high risk of hyperstimulation?
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Does supplementation with recombinant luteinizing hormone prevent ovarian hyperstimulation syndrome in down regulated patients undergoing recombinant follicle stimulating hormone multiple follicular stimulation for IVF/ET and reduces cancellation rate for high risk of hyperstimulation?

机译:在接受重组卵泡刺激素多次卵泡刺激IVF / ET的下调患者中,补充重组黄体生成激素是否可以预防卵巢过度刺激综合征并降低高刺激过度风险的抵消率?

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Aim of this study was to assess the efficacy of recombinant luteinizing hormone (rLH) supplementation in late follicular phase in multiple follicular stimulation with recombinant follicle stimulating hormone (rFSH) in Triptoreline down-regulated patients undergoing IVF, on preventing clinical OHSS and cycles cancellation for OHSS risk. Nine hundred ninety-nine patients aged
机译:这项研究的目的是评估雷公藤碱下调IVF患者在卵泡后期补充重组促黄体生成素(rLH)对多次卵泡刺激与重组卵泡刺激素(rFSH)的预防临床OHSS和周期取消的功效OHSS风险。在开始rFSH刺激以恢复卵母细胞之前,对499位40岁基础FSH≤12 mUI / Ml的患者进行了下调。将患者分为两组:(A)(501例)用150 IU rFSH治疗,最终在刺激的第7天调整rFSH剂量,直到重组人绒毛膜促性腺激素(rhCG)给药为止;(B)(498例)用150 IU rFSH治疗从刺激的第7天开始,直到给予rhCG并同时调整rFSH为止,rFSH和75 IU rLH。 E2 B组中rhCG的天数较高(p <0.0001); A组因卵巢过度刺激综合征(OHSS)风险被取消的周期数(42 / 8.3%)高于B组(12 / 2.4%)(p <0.000001)。我们观察到B组的妊娠率比A组高(16.8%比11.9%)(p <0.05),并且A组的临床OHSS数量也比B组要大(p <0.05)。

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