Primary giant cell malignant fibrous histiocytoma of the ovary: case report and review of the literature.

摘要

Primary sarcomas represent 2-3% of all female genital tract malignancies; only 10% of these are extra-uterine [1]. Malignant fibrous histiocytoma (MFH) arises from primitive mesenchymal cells and is the most common sarcoma of late adult life [2]. Under the World Health Organization re-classification (2002), four subtypes exist with varying prevalence: storiform/pleomorphic MFH (undifferentiated high-grade pleomorphic sarcoma, 60%), myxoid MFH (myofibrosarcoma, 25%), giant cell MFH (undifferentiated pleomorphic sarcoma with giant cells, 10%), and inflammatory MFH (undifferentiated pleomorphic sarcoma with prominent inflammation, 5%) [3]. Only 5 cases of primary MFH of the ovary have been reported and encompass the inflammatory, pleomorphic, and myxoid variants (Table 1). We now describe the first instance of giant cell MFH arising from the ovary.