Insulin resistance, viral load and response to peginterferon and ribavirin in patients with chronic hepatitis C virus infection.

Dai CY; Huang JF; Hsieh MY; Chuang WL; Yu ML

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Insulin resistance, viral load and response to peginterferon and ribavirin in patients with chronic hepatitis C virus infection.

机译：慢性丙型肝炎病毒感染患者的胰岛素抵抗，病毒载量以及对聚乙二醇干扰素和利巴韦林的反应。

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We read the article by Moucari et al in Cut recently1 with great interest. The authors concluded that insulin resistance (IR) is correlated independently with serum hepatitis C virus (HCV)-RNA and frequently encountered in patients with HCV genotype 4 (HCV-4) infection. Also IR is a major predictor of response to peginterferon and ribavirin in 108 HCV-4 patients receiving a 48-week course of peginterferon plus ribavirin.

机译：我们非常感兴趣地阅读了Moucari等人最近在Cut 1上的文章。作者得出的结论是，胰岛素抵抗（IR）与血清丙型肝炎病毒（HCV）-RNA独立相关，并且在HCV基因型4（HCV-4）感染的患者中经常遇到。另外，IR是接受聚乙二醇干扰素加利巴韦林治疗48周的108名HCV-4患者对聚乙二醇干扰素和利巴韦林反应的主要预测指标。

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《Gut: Journal of the British Society of Gastroenterology》 |2010年第3期|共1页
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Dai CY; Huang JF; Hsieh MY; Chuang WL; Yu ML;
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正文语种 eng
中图分类消化系及腹部疾病;
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1. Insulin resistance, viral load and response to peginterferon and ribavirin in patients with chronic hepatitis C virus infection. [J] . Dai CY, Huang JF, Hsieh MY, Gut: Journal of the British Society of Gastroenterology . 2010,第3期

机译：慢性丙型肝炎病毒感染患者的胰岛素抵抗，病毒载量以及对聚乙二醇干扰素和利巴韦林的反应。
2. Whole-body insulin sensitivity index is a highly specific predictive marker for virological response to peginterferon plus ribavirin therapy in chronic hepatitis C patients with genotype 1b and high viral load. [J] . Mizuta T, Kawaguchi Y, Eguchi Digestive Diseases and Sciences . 2010,第1期

机译：全身胰岛素敏感性指数是基因型1b和高病毒载量的慢性丙型肝炎患者对聚乙二醇干扰素联合病毒唑治疗的病毒学应答的高度特异性的预测指标。
3. Whole-Body Insulin Sensitivity Index Is a Highly Specific Predictive Marker for Virological Response to Peginterferon Plus Ribavirin Therapy in Chronic Hepatitis C Patients with Genotype 1b and High Viral Load [J] . Toshihiko Mizuta, Yasunori Kawaguchi, Yuichiro Eguchi, Digestive Diseases and Sciences . 2010,第1期

机译：全身胰岛素敏感性指数是基因型1b和高病毒载量的慢性丙型肝炎患者对聚乙二醇干扰素联合利巴韦林治疗的病毒学应答的高度特异性的预测指标
4. HLA-C gene in Hepatitis C Virus infected Patients in Egypt, to estimate the relation between HLA-C gene and Interferon/Ribavirin as treatment for hepatitis C virus [C] . SHADEN MUAWIA HANAFY, AMAL AHMED ABBAS, SAFY KABEEL ALY MANSOUR International Conference on Cellular and Molecular Biology, Biophysics and Bioengineering . 2015

机译：HLA-C基因在丙型肝炎病毒中感染埃及患者，估计HLA-C基因和干扰素/利巴韦林与丙型肝炎病毒治疗的关系
5. Population pharmacokinetics and efficacy of ribavirin in patients with chronic hepatitis C genotype 1 infection. [D] . Jin, Runyan. 2010

机译：利巴韦林在慢性丙型肝炎基因型1感染患者中的群体药代动力学和功效。
6. Re: Pearlman and Ehleben - Hepatitis C Genotype 1 Virus with Low Viral Load and Rapid Virologic Response to Peginterferon/Ribavirin Obviates a Protease Inhibitor [O] . Alan S. Wang, Ruth M. Pfeiffer, Timothy R. Morgan, -1

机译：回复：Pearlman和Ehleben-低病毒载量和对Peginterferon / Ribavirin的快速病毒学应答的C型肝炎1型病毒消除了蛋白酶抑制剂
7. Peginterferon alfa-2b plus weight-based ribavirin for 24 weeks in patients with chronic hepatitis C virus genotype 1 with low viral load who achieve rapid viral response. [O] . Craxi A, Koutsounas S, Ogurtsov P, 2012

机译：具有低病毒载量的慢性丙型肝炎病毒基因型1的患者，Peginterferon alfa-2b加上基于体重的利巴韦林治疗24周，可实现快速的病毒反应。

Insulin resistance, viral load and response to peginterferon and ribavirin in patients with chronic hepatitis C virus infection.

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