Prucalopride (resolor) in the treatment of severe chronic constipation in patients dissatisfied with laxatives (Gut (2009) 58, (357-365))

摘要

Upper gastrointestinal bleeding (UGIB) is predominantly non-variceal in origin and remains one of the most common challenges faced by gastroenterologists and endoscopists in daily clinical practice. Despite major advances in the approach to the management of non-variceal upper gastrointestinal bleeding (NVUGIB) over the past decade including prevention of peptic ulcer bleeding, optimal use of endoscopic therapy1 and high-dose proton pump inhibition.2 it still carries considerable morbidity, mortality and health economic burden. Although many modernised healthcare systems report reductions in case death over time, most likely attributable to the aforementioned advances in addition to general supportive care, mortality remains appreciably high.