Is combined use of SSRIs and NSAIDs associated with an increased risk of starting peptic ulcer treatment?

摘要

De Jong et?al. [1] reported that the combined use of nonsteroidal anti-inflammatory drugs (NSAIDs) with selective serotonin reuptake inhibitors (SSRIs) synergistically increased the risk of initiating a treatment course with peptic ulcer drugs as a proxy for gastrointestinal adverse effects. In an attempt to limit confounding by indication, tricyclic antidepressant (TCA) users were used as a control group. As the observed association was not adjusted for potential differences between TCA and SSRI users [1], unmeasured confounding may have affected the estimation of the adverse effects.