EPS: an empirical Bayes approach to integrating pleiotropy and tissue-specific information for prioritizing risk genes

摘要

Motivation: Researchers worldwide have generated a huge volume of genomic data, including thousands of genome-wide association studies (GWAS) and massive amounts of gene expression data from different tissues. How to perform a joint analysis of these data to gain new biological insights has become a critical step in understanding the etiology of complex diseases. Due to the polygenic architecture of complex diseases, the identification of risk genes remains challenging. Motivated by the shared risk genes found in complex diseases and tissue-specific gene expression patterns, we propose as an (E) under bar mpirical Bayes approach to integrating (P) under bar leiotropy and Tissue-(S) under bar pecific information (EPS) for prioritizing risk genes.