PseuRECA: genome annotation and gene context analysis for pseudomonas aeruginosa PAO1

摘要

Today, complete genome sequences are published at an ever-increasing rate. The public release of a genome sequence is usually accompanied by an initial annotation that provides functional predictions for about 50-80% of the open reading frames of the genome (Ilipooulos et al., 2001). Once a genome project is finished and released, its further re-annotation is in principle maintained by the respective research community that keeps track of the updating, correcting and constant improving of the functional evidence for gene products. A routinely automatic re-annotation might thus provide a good basis for this continuous improvement of knowledge about the functions encoded in a genome. However, up to now, only a few attempts have been madeto re-annotate complete genome sequences (Ouzounis and Karp, 2002).