【24h】

Flexible ordering of antibody class switch and V(D)J joining during B-cell ontogeny

机译:B细胞个体发育过程中抗体类别开关和V(D)J连接的灵活排序

获取原文
获取原文并翻译 | 示例
           

摘要

V(D)J joining is mediated by RAG recombinase during early B-lymphocyte development in the bone marrow (BM). Activation-induced deaminase initiates isotype switching in mature B cells of secondary lymphoid structures. Previous studies questioned the strict ontological partitioning of these processes. We show that pro-B cells undergo robust switching to a subset of immunoglobulin H (IgH) isotypes. Chromatin studies reveal that in pro-B cells, the spatial organization of the Igh locus may restrict switching to this subset of isotypes. We demonstrate that in the BM, V(D)J joining and switching are interchangeably inducible, providing an explanation for the hyper-IgE phenotype of Omenn syndrome.
机译:V(D)J连接是在骨髓(BM)的早期B淋巴细胞发育过程中由RAG重组酶介导的。激活诱导的脱氨酶在次级淋巴结构的成熟B细胞中启动同种型转换。先前的研究对这些过程的严格本体划分提出了质疑。我们显示pro B细胞经历强大的切换到免疫球蛋白H(IgH)同种型的子集。染色质研究表明,在前B细胞中,Igh基因座的空间组织可能会限制切换至同型亚型。我们证明在BM中,V(D)J的加入和转换是可互换诱导的,从而为Omenn综合征的超IgE表型提供了解释。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号