Metal Chelation in Asymmetric Diels-Alder Reaction(II)

摘要

Diels-Alder reaction is one of the most effective methods to prepare complex organic molecules.The reaction provides up to four stereogenic centers in one step.The asymmetric Diels-Alder reaction has been carried out using a chiral auxiliary and a chiral catalyst.Chiral dienophiles were often employed as chiral auxiliaries,derived from many functional groups such as alcohols,amines,oxazolidinones,and sultams.Diels-Alder cycloadditions of chiral dienophiles with cyclopentadiene proceed with diastereofacial selectivity,giving either endo-R or endo-S compounds as a major component,depending on Lewis acids used.