Selective Reduction of Trigonellyl Group to the Corresponding Dihydropyridine in the Presence of Disulfide Group

摘要

For many years, there has been considerable interest in the synthetic method, utility, and biological activity of various dihydropyridines.1 In recent years, based on the redox system, which is analogous to the endogenous NADH-NAD~+ system, we developed a chemical delivery system (CDS), using a dihydropyridine-pyridinium ion redox system for the specific delivery and sustained release of drug in the brain. In this CDS system, the biologically active compound linked to a lipoidal dihydropyridine carrier can crosses the BBB and is then oxidized to the pyridinium ion form in the brain, which is locked and retained in the brain because the increased hydrophilicity hinders BBB permeability (Figure 1).