A Novel Synthesis of N-Methoxy-N-methylamides from 4,6-Pyrimidyl Urethane and Grignard Reagents

摘要

The N-methoxy-N-methylamides (Weinreb amides) have enjoyed tremendous popularity because they react with organometallics (RM,M=Li,MgX) to provide various ketones through stable metal-chelated intermediates without side products.1 Among the various methods for the preparation of N-memoxy-N-methylamides,the condensation of carboxylic acids and N,O-dimethylhydroxylamine hydrochloride (MeONH2MeCl) using peptide coupling reagents has been frequently employed.