Inhibition of Dual-specificity Phosphatase 22 (DUSP22) by PRL-3 inhibitor 1

摘要

Protein phosphorylation is an essential mechanism for human health and disease, which is regulated by the coordinated activities of kinases and phosphatases. Protein phosphorylation occurs predominantly on serine, threonine, and tyrosine residues of eukaryotic proteins and plays critical roles in the regulation of physiological processes including gene expression, proliferation, differentiation, cell cycles arrest, and apoptosis.