Enantioselective Hydrogenation of (E)-and (Z)-Isomeric Ethyl 3-Acetamidobutenoates with Rh-Bisphosphine Complexes:Effects of Substrate Geometry and Solvents on Reaction Rates and Catalyst Reusability

摘要

Enantiopure beta-amino acids are crucial structural features of numerous biologically active natural products as well as important building blocks for the synthesis of beta-peptides and beta-lactam antibiotics.Numbers of stoichiometric chiral auxilaries and catalytic methods have been developed to make chiral beta-amino acids.